Date: Thu, 25 Mar 1999 23:29:48 EST
To: Multiple recipients of list <firstname.lastname@example.org>
Subject: Ibogaine production technology
Ibogaine production requirements will increase significantly once ibogaine
enters clinical practice.
One approach to overcoming production shortages would be to evaluate cell
suspension or cell culturing technologies. These are production methods in
which individual T. iboga cells for instance, would be grown in medium, in two
stages. The first stage would be maximize cell production and the second
stage would be to maximize alkaloid production.
While not current, some citations for reading are as follows:
Peter F. Heinstein, FUTURE APPROACHES TO THE FORMATION OF SECONDARY NATURAL
PRODUCTS IN PLANT CELL SUSPENSION CULTURES, J. of Natural Products, 48(2):2-9,
A. Fontanel and M. Tabata, PRODUCTION OF SECONDARY METABOLITES BY PLANT TISSUE
AND CELL CULTURES. PRESENT ASPECTS AND PROSPECTS, Nestle Research News,
E. John Staba, MILESTONES IN PLANT TISSUE CULTURE SYSTEMS FOR THE PRODUCTION
OF SECONDARY PRODUCTS, J Natural Products, 48(2):203-209, 1985.